Identification of DPB1 Permissive Unrelated Donors Is Highly Likely
نویسندگان
چکیده
منابع مشابه
Non-Permissive HLA-DPB1 Disparity is a Significant Independent Risk Factor for Mortality after Unrelated Hematopoietic Stem Cell Transplantation Running Title: Nonpermissive HLA-DPB1 disparity in unrelated HSCT
Hematology and Bone Marrow Transplantation Unit, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy; Biostatistics Unit, Department of Health Sciences (DISSAL), University of Genova, Italy; Immunogenetics Laboratory, Unit of Immunohematology and Blood Transfusion, Division of Regenerative Medicine and Stem Cell Therapy, San Raffaele Scientific Institute, Milano, Italy; San...
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Studies in unrelated donor (UD) hematopoietic stem cell transplantations (HSCT) show an effect of the matching status of HLA-DPB1 on complications. We analyzed 423 UD-HSCT pairs. Most protocols included T-cell depletion (TCD). All pairs had high-resolution tissue typing performed for 6 HLA loci. Two hundred eightytwo pairs were matched at 10 of 10 alleles (29% were DPB1 matched). In 141 HLAmism...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2017
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2016.10.021